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The Innovative and Novel Computational Impact on Theory and Experiment, or INCITE, program has announced the 2026 Call for Proposals, inviting researchers to apply for access to some of the world’s most powerful high-performance computing systems.
Daniel Jacobson, distinguished research scientist in the Biosciences Division at ORNL, has been elected a Fellow of the American Institute for Medical and Biological Engineering, or AIMBE, for his achievements in computational biology.

Researchers from ORNL have developed a new application to increase efficiency in memory systems for high performance computing. Rather than allow data to bog down traditional memory systems in supercomputers and impact performance, the team from ORNL, along with researchers from the University of Tennessee, Knoxville, created a framework to manage data more efficiently with memory systems that employ more complex structures.

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

Using the Frontier supercomputer at ORNL, researchers have developed a new technique that predicts nuclear properties in record detail. The study revealed how the structure of a nucleus relates to the force that holds it together. This understanding could advance efforts in quantum physics and across a variety of sectors, from to energy production to national security.

A workshop led by scientists at ORNL sketched a road map toward a longtime goal: development of autonomous, or self-driving, next-generation research laboratories.

Melissa Cregger of the Department of Energy’s 91°µÍø has received the Presidential Early Career Award for Science and Engineers, or PECASE, the highest honor bestowed by the U.S. government on outstanding early-career scientists and engineers.

P&G is using simulations on the ORNL Summit supercomputer to study how surfactants in cleaners cause eye irritation. By modeling the corneal epithelium, P&G aims to develop safer, concentrated cleaning products that meet performance and safety standards while supporting sustainability goals.

Phong Le is a computational hydrologist at ORNL who is putting his skills in hydrology, numerical modeling, machine learning and high-performance computing to work quantifying water-related risks for humans and the environment.

The US focuses on nuclear nonproliferation, and ORNL plays a key role in this mission. The lab conducts advanced research in uranium science, materials analysis and nuclear forensics to detect illicit nuclear activities. Using cutting-edge tools and operational systems, ORNL supports global efforts to reduce nuclear threats by uncovering the history of nuclear materials and providing solutions for uranium removal.