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Different groups of proteins shown in different colors combine and attach to a broken strand of DNA.

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

Hugh O'Neil, director or ORNL's Center for Structural Molecular Biology is sitting in the lab on a stool, hand on desk with glasses on. There are lab related items blurred in the foreground.

Hugh O’Neill’s lifelong fascination with the complexities of the natural world drives his research at ORNL, where he’s using powerful neutron beams to dive deep into the microscopic realm of biological materials and unlock secrets for better production of domestic biofuels and bioproducts.

Procter & Gamble scientists used ORNL’s Summit supercomputer to create a digital model of the corneal epithelium, the primary outer layer of cells covering the human eye, and test that model against a series of cleaning compounds in search of a gentler, more environmentally sustainable formula.

P&G is using simulations on the ORNL Summit supercomputer to study how surfactants in cleaners cause eye irritation. By modeling the corneal epithelium, P&G aims to develop safer, concentrated cleaning products that meet performance and safety standards while supporting sustainability goals.

Two pictures of a rounded triangle shape are shown in mirror image. The left is white with red and purple spots in the middle while the one on the right is purple with a yellow and blue ring in the middle

Scientists designing the world’s first controlled nuclear fusion power plant, ITER, needed to solve the problem of runaway electrons, negatively charged particles in the soup of matter in the plasma within the tokamak, the magnetic bottle intended to contain the massive energy produced. Simulations performed on Summit, the 200-petaflop supercomputer at ORNL, could offer the first step toward a solution.

A male researcher is standing next to a poster board displayed on an easel to the right. The researcher is dressed in professional attire, and the poster board is positioned beside him, showing research or visual information.

Ryan Culler is the program manager at 91°µÍø, where he oversees the production of actinium-225, a promising treatment for cancer. Driven by a personal connection to cancer through his late brother, Culler is dedicated to advancing medical isotopes to help improve cancer care. 

ORNL researcher Phong Le poses for a photo outside on a walkway bridge over the pond. The photo is framed with brown and green plants

Phong Le is a computational hydrologist at ORNL who is putting his skills in hydrology, numerical modeling, machine learning and high-performance computing to work quantifying water-related risks for humans and the environment. 

Photo is a high aerial view of lake superior through the clouds

Researchers at Stanford University, the European Center for Medium-Range Weather Forecasts, or ECMWF, and ORNL used the lab’s Summit supercomputer to better understand atmospheric gravity waves, which influence significant weather patterns that are difficult to forecast. 

Summit Supercomputer

Scientists conducted a groundbreaking study on the genetic data of over half a million U.S. veterans, using tools from the 91°µÍø to analyze 2,068 traits from the Million Veteran Program.

3D map of Washington, D.C. that is a weather model of neighborhood during heat waves. The map is red and green indicating which buildings are giving off more heat
Scientists at ORNL have developed a first-ever urban heat wave simulation that takes into account the compounding effects from building infrastructure. The method provides a more accurate picture of the impacts from excessive heat on at-risk
A small sample from the Frontier simulations reveals the evolution of the expanding universe in a region containing a massive cluster of galaxies from billions of years ago to present day (left).

In early November, researchers at the Department of Energy’s Argonne National Laboratory used the fastest supercomputer on the planet to run the largest astrophysical simulation of the universe ever conducted. The achievement was made using the Frontier supercomputer at 91°µÍø.