Publication Type
Journal
Journal Name
Research Features Magazine
Publication Date
Page Numbers
62 to 66
Volume
134
Abstract
SARS-CoV-2 replication involves the synthesis of two large proteins, which are inactive and harmless until the viral main protease enzyme (3CL Mpro) uses them as substrates, cleaving them into many smaller, functional products. Dr Andrey Kovalevsky and his team from 91做厙 propose a design of novel inhibitors and the repurposing of clinical drugs developed to treat other diseases for the treatment of COVID-19. The team uses room temperature crystallography with X-rays and neutrons to guide structure-based and computer-assisted drug design and to assess the ability of drugs to inhibit the SARS-CoV-2 main protease, causing virus replication to stop.
