Leighton Coates STS Instrument Systems Manager Contact 865.574.4620 | COATESL@ORNL.GOV All Publications Substrate Binding Induces Conformational Changes in a Class A β-lactamase That Prime It for Catalysis Mannobiose Binding Induces Changes in Hydrogen Bonding and Protonation States of Acidic Residues in Concanavalin A As Reveale... Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation Preliminary neutron diffraction analysis of challenging human manganese superoxide dismutase crystals Molecular mechanism of enzymatic chlorite detoxification: insights from structural and kinetic studies Active-Site Protonation States in an Acyl-Enzyme Intermediate of a Class A β-Lactamase with a Monobactam Substrate Perdeuteration, Crystallization, Data Collection and Comparison of Five Neutron Diffraction Data Sets of Complexes of Human Galectin-3c A Structural Study of CESA1 Catalytic Domain of Arabidopsis Cellulose Synthase Complex: Evidence for CESA Trimers... Exploring the Mechanism of beta-Lactam Ring Protonation in the Class A beta-lactamase Acylation Mechanism Using Neutron and X... Neutron and high-resolution room-temperature X-ray data collection from crystallized lytic polysaccharide monooxygenase Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crysta... The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source Genetically Encoded Fragment-Based Discovery of Glycopeptide Ligands for Carbohydrate-Binding Proteins Large-volume protein crystal growth for neutron macromolecular crystallography Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography X-ray Crystallographic Studies of Family 11 Xylanase Michaelis and Product Complexes: Implications for the Catalytic Mechanism of Retaining Glycoside Hydrolases Heterologous expression, purification, crystallization and preliminary X-ray analysis of Trichoderma reesei Xylanase II and f... The active site protonation states of perdeuterated Toho-1 beta-lactamase determined by neutron diffraction support a role fo... Structure of the endonuclease IV homologue from Thermotoga maritima in the presence of active-site divalent metal ions The Active Site Protonation States of the class A CTX-M-type perdeuterated Toho-1 β-lactamase Determined by Neutron Diffraction Support a Role for Glu166 as the General Base in Acylation X-ray structure at 1.75Ã… resolution of a norovirus 3C protease linked to an active site-directed peptide inhibitor Purification, crystallization and preliminary crystallographic analysis of a Thermostable Endonuclease IV from Thermotoga mar... Hydrogen Location in Stages of an Enzyme-Catalyzed Reaction: Time-of-Flight Neutron Structure of d-Xylose Isomerase with Bound d-Xylulose NEW SOURCES AND INSTRUMENTATION FOR NEUTRONS IN BIOLOGY... Crystallisation and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michae... Pagination First page « First Previous page ‹â¶Ä¹ Page 1 Page 2 Current page 3 Key Links