Leighton Coates STS Instrument Systems Manager Contact 865.574.4620 | COATESL@ORNL.GOV All Publications Report on the "Symposium on Advancements in Simulating Neutron Scattering Instruments and Experiments"... Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors Visualizing the Active Site Oxyanion Loop Transition Upon Ensitrelvir Binding and Transient Dimerization of SARS-CoV-2 Main Protease Second Target Station Project: STS Cross-Directorate Workshop on Hydrogen Fuel New Opportunities for Neutrons in Environmental and Biological Sciences Second Target Station Project: STS/PSD/ESTD Workshop on Batteries and Energy Storage Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors Contribution of the catalytic dyad of SARS-CoV-2 main protease to binding covalent and noncovalent inhibitors AI-Accelerated Design of Targeted Covalent Inhibitors for SARS-CoV-2 A realistic guide misalignment model for the Second Target Station instruments at the Spallation Neutron Source ORNL Second Target Station Project: Biological & Environmental Science Workshop Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor Autoprocessing and oxyanion loop reorganization upon GC373 and nirmatrelvir binding of monomeric SARS-CoV-2 main protease catalytic domain Cryo neutron crystallography demonstrates influence of RNA 2′-OH orientation on conformation, sugar pucker and water structure EWALD: A Macromolecular Diffractometer for the Second Target Station The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor Detector needs for STS instruments Cryotrapping peroxide in the active site of human mitochondrial manganese superoxide dismutase crystals for neutron diffraction High-Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Noncovalent Inhibitor Michaelis-like complex of SARS-CoV-2 main protease visualized by room-temperature X-ray crystallography Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease Toho-1 β-lactamase: backbone chemical shift assignments and changes in dynamics upon binding with avibactam Second Target Station Instrument Systems Research and Development Plan Pagination Current page 1 Page 2 Page 3 Next page ›â¶Äº Last page Last » Key Links
