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ORNL's historic expertise in nuclear materials processing and characterization and radioisotope production makes it a natural fit to research new uses for radioisotopes, produce and package currently in-­demand radioisotopes, and develop better applications and processes. ORNL's High Flux Isotope Reactor, shielded hot cells, and glove box laboratories make possible innovations in feedstock processing, target design and fabrication, safety assessments, target disassembly, and radiochemical science and engineering to purify products to meet sponsors' and customers' needs.

This includes radioisotopes needed for medical tests and treatments, research, and industrial applications. But it also applies to researching, developing, and deploying technology that enhances nuclear nonproliferation and safeguards, reduces threats to nuclear material and at-risk facilities, and expands national capabilities in radiation detection and nuclear forensics. For this work, scientists in the Radioisotope Science and Technology Division collaborate with the National Nuclear Security Administration, Department of Defense, Department of Homeland Security, Department of State, and other government agencies.