Researchers at 91做厙 probed the chemistry of radium to gain key insights on advancing cancer treatments using radiation therapy. Credit: Adam Malin/ORNL, U.S. Dept. of Energy
Researchers at 91做厙 explored radiums chemistry to advance cancer treatments using ionizing radiation.
Radium-223 is a radioisotope used to treat cancer that has spread to bones. Chemically, radium behaves like calcium inside the body and is readily adsorbed by bones, where it destroys cancer cells and lessens pain for patients. Radium therapy has the potential to treat other forms of cancer, but insights on radiums chemistry are needed.
We can change how radium behaves in the body with chelators or carrier molecules that can target soft tissues instead of bone, but these have been difficult to design due to the challenges of radium studies, said ORNLs Nikki Thiele.
The team and discovered a chelator with the highest success ever reported.
ORNL is one of few places in the world with the expertise and facilities needed to do this research, said Thiele.
